Adjuvant Treatment for Locally Advanced Rectal Cancer Patients After Preoperative Chemoradiotherapy: When, and for Whom?
作者： Alfonso De Stefano , Roberto Moretto , Luigi Bucci , Stefano Pepe , Francesco Jacopo Romano
DOI: 10.1016/J.CLCC.2014.05.004
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摘要: Abstract Background The standard treatment for patients with locally advanced rectal cancer (clinical tumor, node, metastases [TNM] stage II or III) is radiotherapy before surgery (with without concomitant fluoropyrimidine-based chemotherapy) followed by surgery. role of adjuvant chemotherapy in this setting controversial terms the overall benefit on survival, subgroup who might not need it, and best regimen (combination regimens vs. fluoropyrimidine alone). Patients Methods Based retrospective analysis the clinical outcome all adenocarcinoma treated at our institute during past 9 years, we comment prognostic factors local distant received neoadjuvant surgery, scientific evidence that can help to decide chemotherapy. Results We conclude pathological TNM after chemoradiation (ypTNM) significantly affects disease-free survival. In particular, pathologically positive lymph nodes (ypN+) have a high probability developing metastases. Conclusion ypN+ are candidate intensified
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