Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques
作者： Antonio Valentin , Katherine McKinnon , Jinyao Li , Margherita Rosati , Viraj Kulkarni
DOI: 10.1016/J.CLIM.2014.09.005
关键词:
摘要: To identify the most promising vaccine candidates for combinatorial strategies, we compared five SIV platforms including recombinant canary pox virus ALVAC, replication-competent adenovirus type 5 host range mutant RepAd, DNA, modified vaccinia Ankara (MVA), peptides and protein in distinct combinations. Three regimens used viral vectors (prime or boost) two plasmid DNA. Analysis at necropsy showed that DNA-based elicited significantly higher cellular responses against Gag Env than any of other platforms. The T cell induced by disseminated systemically into secondary lymphoid tissues (lymph nodes, spleen) effector anatomical sites (including liver, vaginal tissue), indicative their role containment portal entry. reported humoral immune response data suggest combination DNA elicits a balanced immunity with strong durable able to disseminate relevant mucosal sites.
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