Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques.

摘要: The induction of a balanced immune response targeting the major structural proteins, Gag and Env HIV, is important for development an efficacious vaccine. use DNA plasmids expressing different antigens offers opportunity to test in controlled manner influence vaccine components on magnitude distribution vaccine-induced cellular humoral responses. Here, we show that increasing amounts env results greatly enhanced antibody titers without significantly affecting levels anti-Env Co-immunization with protein further increased levels, indicating vaccination only not sufficient eliciting maximal responses against Env. In contrast, under high env:gag plasmid ratio, was reduced by either SIV or HIV Env, whereas were affected. Our data indicate ratio 2 ke...