Neoadjuvant long-course chemoradiotherapy for rectal cancer : does time to surgery matter?

摘要: The objective of this paper was to evaluate whether delaying surgery following long-course chemoradiotherapy for rectal cancer correlates with pathologic complete response. Pre-operative (CRT) is standard practice in the UK management locally advanced cancer. Optimal timing CRT still not clearly defined. All patients a diagnosis who had undergone prior between January 2008 and December 2011 were included. Statistical analysis performed using Stata 11. Fifty-nine received selected period. Twenty-seven percent (16/59) showed histopathologic response 59.3% (35/59) tumor down-staging from radiologically-assessed node positive histologically-proven negative disease. There no statistically significant delay after completion 16 (CR) compared rest group [IR: incomplete response; CR median: 74.5 days (IQR: 70-87.5) IR 72 57-83), P = 0.470]. Although predictors either or nodal status identified logistic regression analyses, trend toward seen longer CRT.