Delayed surgery after radio-chemotherapy for rectal adenocarcinoma is protective for anastomotic dehiscence: a single-center observational retrospective cohort study.

摘要: Ideal time interval between end of neoadjuvant radio-chemotherapy (NRCT) and surgery for rectal cancer is debated. Effect that different intervals have on postoperative complications with particular regard to anastomotic dehiscence (AD) was evaluated 167 patients who underwent after long-course NRCT. Three were considered: (0–42; 43–56; > 57 days). A interval > 57 days significantly protective AD (p = 0.04, Odds ratio = 0.35; 95% CI 0.1254–0.9585) without influence early oncological outcomes. Optimal NRCT may help achieving the best pathological response lowest morbidity. Trial registration number: Clinical Trial. Gov NCT04013347. https://clinicaltrials.gov/ct2/results?cond=&term=NCT04013347&cntry=&state=&city=&dist= ).