LncRNA Xist, X-chromosome Instability and Alzheimer's Disease.

摘要: Neurodegenerative diseases (NDD) are the major contributors to age-related causes of mental disability on a global scale. Most NDDs, like Alzheimer's Disease (AD), complex in nature - implying that they multi-parametric both terms heterogeneous clinical outcomes and underlying molecular paradigms. Emerging evidence from high throughput genomic, transcriptomic small RNA sequencing experiments hint at roles long non-coding RNAs (lncRNAs) AD. X-inactive specific transcript (XIST), component Xic, X-chromosome inactivation centre, is an gene X chromosome placental mammals indispensable for process. An extensive literature survey shows aberrations Xist expression some cases, disruption as whole play significant role Considering enormous potential endogenous silencing molecule, idea using non-conventional silencer treat harboring chromosomal alterations also being implemented. Comprehensive knowledge about how could such AD still elusive. In this review, we have collated available possible involvement deregulation perspective mechanisms governing NDDs with primary focus disease. Possibilities XIST mediated therapeutic intervention linkages between XIC preferential predisposition females been discussed.