An alternative mechanism for the production of hydroxyl radicals by stimulated neutrophils.

摘要: The importance of oxygen in the microbiocidal activity polymorphic leukocytes has been established1 for many years. Twenty years ago it was shown2 that two-electron reduction product oxygen, hydrogen peroxide, is present medium surrounding stimulated cells. Later, superoxide ion, one-electron reuction also found3 to be produced by phagocytosing neutrophils. three-electon product, hydroxyl radical, since found4 these activated A flurry mechanisms, seeking account genesis of, and relationship between, potentially reactive species resulted. It now generally accepted ion produced5 a membrane-bound enzyme requires NAD(P)H. not yet known whether peroxide found extracellularly arises direct or through spontaneous disproportionation superoxide: $$ {O_2} + 2e 2H \to {H_2}{O_2}\ $$ (1) $$ 20_{2}^{-}+2{{H}^{+}}\to {{H}_{2}}{{O}_{2}}+{{O}_{2}} $$ (2)