Dietary fat modulation of murine mammary tumor metabolism studied by in vivo 31P-nuclear magnetic resonance spectroscopy.

摘要: The effect of dietary fat concentration and saturation on high energy phosphate metabolites phospholipid turnover in transplanted line 168 murine mammary tumors was studied using surface coil 31P-nuclear magnetic resonance spectroscopy. Female BALB/c mice were fed one five diets each containing at least the minimum essential fatty acids (EFA). Four contained additional safflower or palm oil for a total 5 20% by weight. growth rate from diet significantly greater than all other including which minimal EFA. resonance-observable metabolite ratios. ATP/Pi, ATP/phosphomonoester (ATP/PME), PME/Pi, tumor pH decreased with increasing volume, indicating shift active to inactive metabolism. rates those decreases progressive differed among different diets. Decreases ATP/PME, most rapid faster In addition, decrease PME/Pi ratio (high oil) decline ATP/Pi ATP/PME directly correlated levels linoleic acid as well unsaturated fat. High polyunsaturated had significant metabolism particularly during early stages growth. Differences dynamics relative present equal volume. Thus, influences tumorigenesis may be related metabolites.