Fluorinated and un-fluorinated N-halamines as antimicrobial and biofilm-controlling additives for polymers

摘要: Abstract The objective of this study was to evaluate the effects fluorination on antimicrobial and biofilm-controlling activities N-halamine-based additives for polymers. A fluorinated N-halamine, 1-chloro-3-1H,1H,2H,2H-perflurooctyl-5,5-dimetylhydantoin (Cl-FODMH), its un-fluorinated counterpart, 1-chloro-3-octyl-5,5-dimethylhydantoin (Cl-ODMH), were synthesized characterized with FT-IR, 1 H NMR, DSC studies. Polyurethane (PU) films containing Cl-ODMH Cl-FODMH as fabricated through solvent casting. With same additive contents (1wt%-5 wt%), PU showed higher contact angle values. AFM, SEM results revealed that while distributed evenly within PU, aggregated formed macro-domains in PU. Antimicrobial studies had potency against Gram-positive Gram-negative bacteria than samples Cl-FODMH. These demonstrated importance distribution polymers performances, shedding lights future material design strategies.