作者: Jan Erik Duus , Shelly S. Lo , Kathy S. Albain
DOI: 10.1007/978-3-540-28266-2_18
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摘要: The heterogeneity of breast cancer is well understood both biologically and in the practice setting. On one hand, it not uncommon for some patients to survive years despite presence widely advanced or metastatic disease. In contrast, with localized tumors may relapse rapidly adequate surgical medical treatment. Age has long been considered have a strong association this varying clinical behavior, older being more likely indolent disease, younger tending aggressive course. Recognizing unique nature disease population, 1993 National Institutes Health (NIH) sponsored conference discuss various aspects women. consensus statements were published Journal Cancer Institute Monographs [99]. Since then, multiple panels acknowledged young age as an adverse prognostic factor [29, 43, 45], although controversy regarding treatment still exists. Thus, appropriate consider special scenario young, premenopausal patient, specific focus on whether therapy should be tailored different manner than postmenopausal patients.