13.30 – Excitotoxicity*

摘要: Excitotoxicity refers to neuronal death caused by the overactivation of excitatory amino acid receptors. Several lines evidence have linked excitotoxicity pathogenesis both acute and chronic neurologic diseases. Research into mechanisms excitotoxic injury has associated activation receptors free radical generation nitric oxide, which in turn leads oxidative stress. Downstream enzymatic effectors include a mix proteases, radicals, endonucleases. Excitatory acids play role neurological diseases such as stroke, trauma, hypoglycemia; their too been supported studies using animal models work with glutamate release inhibitor amyotrophic lateral sclerosis. Chronic Alzheimer’s disease, Huntington’s Parkinson’s disease. Despite overwhelming these variety pharmacological interventions aimed at inhibiting processes, very few treatments shown efficacy clinical trials. As such, recent research directed nonglutamate ion channels responsible for ionic imbalance well cross-talk between cell pathways implicated excitotoxicity.