Role of inhibitory control in modulating spread of focal ictal activity

摘要: Focal seizure propagation is classically thought to be spatially contiguous. However, through the epileptic network, a collection of disparate nodes, has been theorized. Here, we used multielectrode array, wide field calcium imaging, and two-photon imaging study focal pathways in an acute rodent neocortical 4-aminopyridine model. Although ictal neuronal bursts did not beyond 2-3 mm region, they were associated with hemisphere-wide LFP fluctuations parvalbumin-positive interneuron activity outside focus. Globally compromising this inhibitory response using bicuculline surface application resulted classical contiguous propagation; whereas, microinjection network formation two physically foci. Our suggests both could arise from inhibition defects without pre-existing pathological connectivity changes, that preferred may result variations cortical topology.