Case series of the long-term psychosocial impact of drug- resistant tuberculosis in HIV-negative medical doctors

摘要: BACKGROUND: Health care workers (HCWs) are at greater risk for tuberculosis (TB) including multidrug-resistant TB (MDR-TB) compared to the general population. The psychosocial impact of nosocomial on HCWs has received little attention in literature. METHODS: A retrospective medical record review from 1999 2003 found 15 who were treated drug-resistant a specialist hospital South Africa. Five human immunodeficiency virus (HIV) negative doctors with no predisposing factors drug resistance included this case series. We collectively present their clinical histories based records 2000 2005 and explore long-term interviews conducted 2009. RESULTS: Four had primary MDR-TB one multiple first-line drugs. Time symptom onset commencement effective treatment ranged 8 39 weeks. bacteriological confirmation 6 24 All cured within 3 years initial presentation. Content analysis follow-up revealed five main themes: 1) prolonged morbidity 2) psychological 3) poor infection control 4) weak support structures 5) attrition field. CONCLUSION: Themes emergent series encourage prioritisation education practice minimise HCW prevent high-burden resource-constrained settings.