Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio

摘要: Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled- Wave Analysis simulations predict a more tightly confined resonant electric field the surface of this biosensor as compared to previously fabricated near-infrared biosensors. This change in provides an improvement over 4.5 times surface-sensitivity bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed surface. These new biosensors can be mass by replica molding. They especially well suited applications requiring small molecules ultra-low analyte concentrations.