Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study.
作者： Andrew J. Park , Ricardo A. Battaglino , Nguyen M. H. Nguyen , Leslie R. Morse
DOI: 10.1371/JOURNAL.PONE.0198969
关键词:
摘要: Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. levels are positively correlated with BMI in the spinal cord injury population leptin greater individuals compared to uninjured controls. produced multiple tissues, including fat, bone, skeletal muscle putative biomarker of sedentary behavior older adults. We assessed body composition leptin, adiponectin, IL-6 205 men chronic injury. found no association between age, duration, level, completeness, or walking status leptin. There was significant positive lean mass SCI independent fat. Adjusting for composition, were associated negatively adiponectin levels. When considering sarcopenic obesity, only fat remained IL-6, obesity group. Our findings suggest under recognized, but substantial, source circulating Furthermore, SCI-related may result dysregulated metabolism local systemic physiologic effects.
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