The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

摘要: Muscle- and liver-derived IGF-1 play important roles in muscle anabolism throughout growth aging. Yet, prolonged food restriction is thought to increase longevity part by lowering levels of IGF-1, which turn reduces the risk for developing various cancers. The dietary factors that modulate are, however, poorly understood. We tested hypothesis adipokine leptin, elevated with intake suppressed during fasting, a key mediator aging restriction. First, leptin peripheral tissues were measured young mice fed ad libitum, aged calorie-restricted (CR) mice. A group CR also treated recombinant 10 days. Later, libitum saline (VEH) or novel receptor antagonist peptide (Allo-aca) tissue-specific determined. On one hand, induced three-fold two-fold muscle-derived aged, Leptin significantly increased serum hormone other, Allo-aca did not alter body weight mass compared VEH did, produce significant (20%) decline as well an even more pronounced (>50%) decrease VEH-treated reduced accompanied any change These findings suggest antagonists may represent therapeutic agents attenuating signaling associated aging, could potentially mimic some positive effects calorie on longevity.