Effect of mixing of fine carrier particles on dry powder inhalation property of salbutamol sulfate (SS)

摘要: The most commonly used formulations for dry powder inhalations are binary ordered mixes composed of micronized drugs and coarse carriers. An optimal aerosol formulation should possess an inhalation property a good flow property. These characteristics especially important multidose inheler (DPI). In the present study, model blend were prepared consisting synthesized sugar (different particle sized isomalt; IM-PF, IM-FS, IM-F) as carrier salbutamol sulfate (SS). mixtures aerosolized by JAGO DPI (SkyePharma AG) in vitro deposition properties (fine fraction, FPF) evaluated twin impinger (TI) at rate 60 l/min. separation between SS particles was investigated centrifuge method air jet sieve (AJS) method. It found that FPF decreased with increasing size. However, large possesses Therefore, effect mixing fine (IM-PF) into (IM-FS) on investigated. When proportion IM-PF carrier) increase from 0% to 25% total blend, also increases 16.7% 38.9%. is concluded might be suitable improving properties.