Ethacrynic acid and furosemide

摘要: Abstract Ethacrynic acid and furosemide are the most potent diuretic agents currently available. Although evidence for a proximal tubular site of action is conflicting, main both inhibition sodium reabsorption along ascending loop Henle. Acute administration ethacrynic may produce transient slight increase in glomerular filtration rate renal plasma flow, which followed by decrease flow with diuresis dehydration. In patients who do not have congestive heart failure, acute either drug results volume, central venous pressure cardiac index, an arteriovenous oxygen differences. severe volume fall, but index increases difference narrows. Both drugs rapid short duration wide steep dose-response curves. Therefore, can be used mild to failure or fluid retention. also effective despite presence hypoalbuminemia, acid-base electrolyte imbalance low rate. refractoriness agent unusual absence failure. Neither has been widely antihypertensive therapy. No marked potency from that standard thiazide noted. especially useful those hypertension concomitant this group they help maintain adequate urinary output potentiate other drugs. Despite drugs, side effects relatively infrequent. However, close monitoring response, status recommended.