Cell signaling in trophoblast-uterine communication

摘要: Intricate and precise communication between the blastocyst uterus orchestrates embryo implantation. However, many questions remain unanswered regarding molecular complexities of On-time implantation requires a receptive mature with trophoblast cells capable adhering to invading endometrium. Defects in uterine receptivity or embryo/uterine signaling can cause failure early pregnancy loss, whereas deficient differentiation generate placental abnormalities that produce adverse outcomes. This review will discuss several examples pathways regulate development during this period. Leukemia inhibitory factor is involved priming for The epidermal growth system contributes trophoblast-uterine communication, as well adhesion invasion. Indian hedgehog synchronizes tissue compartments within uterus, WNT mediates numerous interactions site developing placenta. autocrine, paracrine juxtacrine mediated by these contribute significantly establishment pregnancy, although there are other known yet be discovered factors synchronize maternal embryonic developmental programs.