History of oocyte and embryo metabolism

摘要: The basic pattern of metabolism in mammalian oocytes and early embryos was established the 1960s 1970s, largely terms consumption oxygen utilisation nutrients present culture media at time, mainly glucose, pyruvate lactate. potential importance endogenous fuels also recognised but ignored, only to be rediscovered quite recently. 1980s 1990s saw arrival a 'new generation' media, characterised metabolically by addition amino acids, an initiative driven strongly need improve embryo selection methods assisted reproductive technologies. This trend has continued alongside some metabolic studies general recognition all aspects biology. A framework for future on oocyte been provided by: (1) developmental origins health disease concept relationship between development, epigenetics metabolism; (2) understand cell signalling within, cells of, embryo; (3) identifying mechanisms underlying dialogue female tract.