New solid state forms of antineoplastic 5-fluorouracil with anthelmintic piperazine

作者: C. Moisescu-Goia , M. Muresan-Pop , V. Simon

DOI: 10.1016/J.MOLSTRUC.2017.08.076

关键词:

摘要: Abstract The aim of the present study was to asses formation solid forms between 5-fluorouracil chemotherapy drug and anthelmintic piperazine. Two new antineoplastic agent with piperazine were obtained by liquid assisted ball milling slurry crystallization methods. N H hydrogen bonding donors C = O acceptors allow form co-crystals other drugs delivering improved properties for medical applications, as proved compounds pharmaceutical interest. Both investigated using X-ray powder diffraction (XRD), differential thermal analysis (DTA) Fourier transform infrared (FTIR) spectroscopy. XRD results show that both methods successfully synthesized According FTIR prepared lichid grinding process co-crystal one, method, resulted a salt.

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