Compounds and methods for kinase modulation, and indications therefor

摘要: Compounds and salts thereof, formulations conjugates derivatives forms thereof uses are described. In certain aspects embodiments, the described compounds or active on at least one Raf protein kinase. in inhibiting proliferation of a Ras mutant cell line. Also methods use to treat diseases conditions, including conditions associated with activity B-Raf V600E kinase, melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid lung ovarian prostate liver gallbladder gastrointestinal stromal tumors, biliary tract cholangiocarcinoma. c-Raf-1 acute pain, chronic pain polycystic kidney disease.