H. pylori-Eradication Therapy Increases RUNX3 Expression in the Glandular Epithelial Cells in Enlarged-Fold Gastritis

摘要: Helicobacter pylori (HP)-eradication therapy increases Runt domain transcription factor 3 (RUNX3) expression in the glandular epithelial cells enlarged-fold gastritis. The aim of this study is to evaluate RUNX3 protein, product a gastric tumor suppression gene, and mutagenic oxidative stress human mucosal specimens obtained from patients with HP-induced Methods. was immunohistochemically scored degree directly measured by chemiluminescense (ChL) assay biopsy specimens. Results. detected cells. HP-eradication significantly increased epithelium corpus, however, no change observed those antrum. A fourfold higher ChL value corpus as compared that decreased values both portions stomach nearly undetectable levels. Conclusion. exposed high level carcinogenic shows low levels suppressive molecule, RUNX3; restored after HP-eradication, suggesting risk carcinogenesis associated gastritis corpus.