Trypsin-inspired poly(urea-urethane)s containing phenylalanine-lysine ethyl ester-phenylalanine units
作者： Fangjie Wang , Zhen Zheng , Wei Wang , Zhenqian Gu , Jing Wang
DOI: 10.1016/J.POLYMDEGRADSTAB.2013.12.007
关键词:
摘要: Abstract A novel tri-peptide derivative phenylalanine-lysine ethyl ester-phenylalanine (PLP) was synthesized by carbodiimide hydrochloride (EDC·HCl) mediated coupling reaction from phenylalanine and lysine ethyl ester in the presence of NHS. Then PLP used as a chain extender to synthesize kind trypsin-inspired poly(urea-urethane)s (PLP-PU) with polyethylene glycol (PEG) soft segment hexamethylene diisocyanate (HDI) hard segment. Enzymatic degradation tests showed that PLP unit very sensitive trypsin its solution. Experimental results indicated that degradability obviously improved introducing into main poly(urea-urethane) because effectively broken action process degradation.
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