Exploring the effect of D61G mutation on SHP2 cause gain of function activity by a molecular dynamics study
作者： Hong-Lian Li , Ying Ma , Chang-Jie Zheng , Wen-Yan Jin , Wen-Shan Liu
DOI: 10.1080/07391102.2017.1402709
关键词:
摘要: … networks analysis, the hydrogen bond occupancy analysis and … MD simulations for the two proteins obtained above were … correlation between the two atoms was positively correlated …
sci-hub.se 参考文章(39)
Marco Tartaglia, Ernest L. Mehler, Rosalie Goldberg, Giuseppe Zampino, Han G. Brunner, Hannie Kremer, Ineke van der Burgt, Andrew H. Crosby, Andra Ion, Steve Jeffery, Kamini Kalidas, Michael A. Patton, Raju S. Kucherlapati, Bruce D. Gelb, Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nature Genetics. ,vol. 29, pp. 465- 468 ,(2001) , 10.1038/NG772
Heirie M. M. Mendez, John M. Opitz, James F. Reynolds, Noonan syndrome: a review. American Journal of Medical Genetics. ,vol. 21, pp. 493- 506 ,(1985) , 10.1002/AJMG.1320210312
Nadine Homeyer, Holger Gohlke, Free Energy Calculations by the Molecular Mechanics Poisson-Boltzmann Surface Area Method. Molecular Informatics. ,vol. 31, pp. 114- 122 ,(2012) , 10.1002/MINF.201100135
Tomoki Nakamura, Melissa Colbert, Maike Krenz, Jeffery D. Molkentin, Harvey S. Hahn, Gerald W. Dorn, Jeffrey Robbins, Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome Journal of Clinical Investigation. ,vol. 117, pp. 2123- 2132 ,(2007) , 10.1172/JCI30756
Peter A. Kollman, Irina Massova, Carolina Reyes, Bernd Kuhn, Shuanghong Huo, Lillian Chong, Matthew Lee, Taisung Lee, Yong Duan, Wei Wang, Oreola Donini, Piotr Cieplak, Jaysharee Srinivasan, David A. Case, Thomas E. Cheatham, Calculating Structures and Free Energies of Complex Molecules: Combining Molecular Mechanics and Continuum Models Accounts of Chemical Research. ,vol. 33, pp. 889- 897 ,(2000) , 10.1021/AR000033J
Luciana Musante, Hans G Kehl, Frank Majewski, Peter Meinecke, Susann Schweiger, Gabriele Gillessen-Kaesbach, Dagmar Wieczorek, Georg K Hinkel, Sigrid Tinschert, Maria Hoeltzenbein, Hans-Hilger Ropers, Vera M Kalscheuer, Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome. European Journal of Human Genetics. ,vol. 11, pp. 201- 206 ,(2003) , 10.1038/SJ.EJHG.5200935
Toshiyuki Araki, M Golam Mohi, Fraz A Ismat, Roderick T Bronson, Ifor R Williams, Jeffery L Kutok, Wentian Yang, Lily I Pao, D Gary Gilliland, Jonathan A Epstein, Benjamin G Neel, Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation Nature Medicine. ,vol. 10, pp. 849- 857 ,(2004) , 10.1038/NM1084
Wolfgang Kabsch, Christian Sander, None, Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features Biopolymers. ,vol. 22, pp. 2577- 2637 ,(1983) , 10.1002/BIP.360221211
Laercio Pol-Fachin, Claudia Lemelle Fernandes, Hugo Verli, GROMOS96 43a1 performance on the characterization of glycoprotein conformational ensembles through molecular dynamics simulations. Carbohydrate Research. ,vol. 344, pp. 491- 500 ,(2009) , 10.1016/J.CARRES.2008.12.025
Heike Keilhack, Frank S. David, Malcolm McGregor, Lewis C. Cantley, Benjamin G. Neel, Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. Journal of Biological Chemistry. ,vol. 280, pp. 30984- 30993 ,(2005) , 10.1074/JBC.M504699200