Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes.

作者: Jingwei Wu , Yingzhan Sun , Hui Zhou , Ying Ma , Runling Wang

DOI: 10.1080/07391102.2019.1654410

关键词:

摘要: PTP-MEG2 plays a significant role in insulin production and is able to enhance signaling improve sensitivity. So, inhibitors are closely associated with type 2 diabetes...

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