Prenatal development of the gonadotropin-releasing hormone-containing systems in rat brain.

摘要: Pre-embedding immunofluorescence was used to study the development of gonadotropin-releasing hormone (GnRH)-containing neuronal systems in brain fetal and newborn rats. Immunoreactive cell bodies are first seen association with ventral olfactory bulb at embryonic (E) day 15. At E 17, single GnRH-containing neurons found nasal system, along nerve, ganglion terminale, bulb, septum-diagonal band complex, tubercle ventrolateral hypothalamus. A major spurt occurs between days 18 19. 19, immunoreactive present all areas as adult animals, however, smaller number. fibers detected system 17. 18, GnRH positive projections nervus terminalis, developing organum vasculosum lamina terminalis By containing connections established most final target areas. These include caudal lateral septum, stria fimbria hippocampi, habenula, supramammillary commissure central gray. In hypothalamus, 3 pathways recognized: a projection which runs beneath optic chiasm toward median eminence; tract is located projects thalamus well periventricular network habenula and, direction, mediobasal hypothalamus including eminence. The results suggest that develop considerably earlier than previously reported intracerebral fiber several before birth.