Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos.
作者： E. Kaufmann , H. Paul , H. Friedle , A. Metz , M. Scheucher
DOI: 10.1002/J.1460-2075.1996.TB01063.X
关键词:
摘要: Transcription of the early response gene XFD-1' (XFKH1) in dorsal lip (Spemann organizer) Xenopus embryos is activated by mesoderm inducing factors. Promoter studies revealed presence an activin A element (ARE) which both necessary and sufficient for transcriptional activation reporter genes animal cap explants incubated with A. Surprisingly, this ARE also active within vegetal absence exogenously added inducers, but additional inhibitory prevents transcription ventral/vegetal region embryo vivo. This located upstream ARE, it responds to bone morphogenic proteins 2 4 (BMP-2/4) triggered signals overrides activating properties ARE. Expression patterns BMP-2 BMP-4 late blastula stage and, especially, their from blastopore may thus control spatial gene. Accordingly, temporal restriction activity Spemann organizer regulated antagonistic actions two distinct members TGF-beta family (activin BMP) act on different promoter elements.
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