Signal transduction mechanisms for members of the TGF-β family
作者： Carl-Henrik Heldin , Aristidis Moustakas , Serhiy Souchelnytskyi , Susumu Itoh , Peter ten Dijke
DOI: 10.1007/978-3-0348-8354-2_2
关键词:
摘要: The transforming growth factor-β (TGF-β) superfamily consists of about 30 mammalian members, including TGF-β isoforms, activins, bone morphogenetic proteins (BMPs), Mullerian inhibiting substance (MIS) and others (reviewed by [1]). These factors regulate cell growth, differentiation apoptosis various types, have important functions during the embryonal development. isoforms inhibit most epithelial cells, endothelial cells lymphocytes; however, certain connective tissue is stimulated. also causes an accumulation extracellular matrix molecules, via stimulation f synthesis as well inhibition degradation, triggers IgA class switch B lymphocytes. Activins stimulate secretion follicle stimulating hormone from pituitary promote erythropoietic survival neuronal tissue, induce dorsal mesoderm in Xenopus embryos. BMPs cartilage vivo, affect hematopoietic stem neural ventral Xenopus. Overactivity or loss activity members family has been implicated disorders, fibrotic conditions, rheumatoid arthritis cancer.
springer.com
sci-hub.st 参考文章(158)
E. Kaufmann, H. Paul, H. Friedle, A. Metz, M. Scheucher, J. H. Clement, W. Knöchel, Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos. The EMBO Journal. ,vol. 15, pp. 6739- 6749 ,(1996) , 10.1002/J.1460-2075.1996.TB01063.X
R. Wieser, J.L. Wrana, J. Massagué, GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. The EMBO Journal. ,vol. 14, pp. 2199- 2208 ,(1995) , 10.1002/J.1460-2075.1995.TB07214.X
Darryl Carter, Taiping Chen, Michael Reiss, Laure Garrigue-Antar, Transforming Growth Factor β Type I Receptor Kinase Mutant Associated with Metastatic Breast Cancer Cancer Research. ,vol. 58, pp. 4805- 4810 ,(1998)
Jeffrey L Wrana, Liliana Attisano, Rotraud Wieser, Francesc Ventura, Joan Massagué, None, Mechanism of activation of the TGF-β receptor Nature. ,vol. 370, pp. 341- 347 ,(1994) , 10.1038/370341A0
Xin Chen, Ellen Weisberg, Valerie Fridmacher, Minoru Watanabe, Grace Naco, Malcolm Whitman, Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature. ,vol. 389, pp. 85- 89 ,(1997) , 10.1038/38008
A Gougos, M Letarte, Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. Journal of Biological Chemistry. ,vol. 265, pp. 8361- 8364 ,(1990) , 10.1016/S0021-9258(19)38892-1
Jaeseob Kim, Kirby Johnson, Hui Ju Chen, Sean Carroll, Allen Laughon, Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic Nature. ,vol. 388, pp. 304- 308 ,(1997) , 10.1038/40906
Mineo Kurokawa, Kinuko Mitani, Kenji Irie, Tomohiro Matsuyama, Tokiharu Takahashi, Shigeru Chiba, Yoshio Yazaki, Kunihiro Matsumoto, Hisamaru Hirai, The oncoprotein Evi-1 represses TGF-Beta signalling by inhibiting Smad3 Nature. ,vol. 394, pp. 92- 96 ,(1998) , 10.1038/27945
Ying Zhang, Xin-Hua Feng, Rik Derynck, Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. ,vol. 394, pp. 909- 913 ,(1998) , 10.1038/29814
Luis Ulloa, Jacqueline Doody, Joan Massagué, Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway Nature. ,vol. 397, pp. 710- 713 ,(1999) , 10.1038/17826