Gene Expression Changes in Kindling

摘要: Kindling is a phenomenon by which the periodic application of an initially subconvulsive electrical stimulus results in progressive development epileptiform activity, culminating manifestation generalized seizures response to stimulus. Once animal kindled, enhanced state excitability permanent1, 2, 3, 4, 5 stimulation can produce great number effects, any could contribute epileptogenic state. Many studies have shown interactions between kindling and neurotransmitter systems,6, 7, 8, 9, 10, 11 second messengers,12, 13, 14 ion channels.15, 16, 17 Histological with light electron microscopy also reveal neural structure changes mossy fiber sprouting kindled animals.18, 19, 20 Thus, produces both structural chemical changes, many are associated or result from gene expression. This chapter focuses on regulator G-protein signaling (RGS), Ca2+/calmodulin-dependent protein kinase II (CaMK II) expression, long-lasting expression kindling.