Tamoxifen usage correlates with increased risk of Parkinson’s disease in older women with breast cancer: a case–control study in Taiwan

摘要: Little is known about the association between tamoxifen usage and risk of Parkinson’s disease in women with breast cancer. The present study aimed to evaluate older cancer Taiwan. We conducted a retrospective nationwide case–control using database Taiwan National Health Insurance Program. In total, 293 female subjects cancer, aged 65 years above, who were newly diagnosed 2000 2011 included. Additionally, 1053 above without randomly selected as controls. Both cases controls matched for age comorbidities. Ever use was defined had at least prescription before index date, whereas never those date. used unconditional logistic regression model calculate odds ratio (OR) 95% confidence interval (CI) disease. After adjusting confounding variables, adjusted OR 3.32 ever (95% CI, 2.50–4.43), compared nonusers. Further analysis showed that ORs 3.21 2.29–4.49), 3.95 2.77–5.64), 11.4 2.63–49.7) < 2, 2–6, ≥ 6 years cumulative usage, respectively, when Tamoxifen associated 3.32-fold increase likelihood having among