Immunohistochemical analysis of ras oncogene p21 product in human gastric carcinomas and their adjacent mucosas.
作者： F. Carneiro , L. David , C. Sunkel , C. Lopes , M. Sobrinho-Simoes
DOI: 10.1016/S0344-0338(11)81203-3
关键词:
摘要: Summary In an attempt to clarify the relationship between ras oncogene expression and clinico-pathological features of malignant premalignant lesions stomach we undertook immunohistochemical study gene p21 product in a series eighty gastric carcinomas their respective adjacent mucosas. two cases mRNA Ha-ras was also studied by situ hybridization. The majority as well non-neoplastic mucosas expressed product. There significant morphologic pattern tumours. An enhanced found several conditions regarded precursor intestinal and!or diffuse types carcinoma (dysplasia, foveolar hyperplasia even neck zone normal-appearing glands, namely mucosa carcinomas). Ras actually more prominent most these than carcinomas. No invasiveness wall, nodal metastases venous invasion.
sci-hub.se 参考文章(58)
George T. Bowden, John Smith, Allan Balmain, Martin Ramsden, Activation of the mouse cellular Harvey- ras gene in chemically induced benign skin papillomas Nature. ,vol. 307, pp. 658- 660 ,(1984) , 10.1038/307658A0
P. G. Chesa, W. J. Rettig, M. R. Melamed, L. J. Old, H. L. Niman, Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 3234- 3238 ,(1987) , 10.1073/PNAS.84.10.3234
Donna George, Manfred Schwab, Kari Alitalo, Harold E. Varmus, J. Michael Bishop, A cellular oncogene (c-Ki- ras ) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells Nature. ,vol. 303, pp. 497- 501 ,(1983) , 10.1038/303497A0
Bogdan Czerniak, Fritz Herz, Leopold G. Koss, Jeffrey Schlom, ras oncogene p21 as a tumor marker in the cytodiagnosis of gastric and colonic carcinomas Cancer. ,vol. 60, pp. 2432- 2436 ,(1987) , 10.1002/1097-0142(19871115)60:10<2432::AID-CNCR2820601014>3.0.CO;2-1
Shóko Mitani, Isamu Sugawara, Hiroshi Shiku, Shigeo Mori, Expression of c-myc oncogene product and ras family oncogene products in various human malignant lymphomas defined by immunohistochemical techniques. Cancer. ,vol. 62, pp. 2085- 2093 ,(1988) , 10.1002/1097-0142(19881115)62:10<2085::AID-CNCR2820621003>3.0.CO;2-R
T. Yamamoto, T. Hattori, E. Tahara, Interaction between transforming growth factor-alpha and c-Ha-ras p21 in progression of human gastric carcinoma. Pathology Research and Practice. ,vol. 183, pp. 663- 669 ,(1988) , 10.1016/S0344-0338(88)80050-5
D C Allen, H Foster, J C Orchin, J D Biggart, Immunohistochemical staining of colorectal tissues with monoclonal antibodies to ras oncogene p21 product and carbohydrate determinant antigen 19-9. Journal of Clinical Pathology. ,vol. 40, pp. 157- 162 ,(1987) , 10.1136/JCP.40.2.157
J.L. Bos, M.Verlaan-de Vries, C.J. Marshall, G.H. Veeneman, J.H. van Boom, A.J. van der Eb, A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogene Nucleic Acids Research. ,vol. 14, pp. 1209- 1217 ,(1986) , 10.1093/NAR/14.3.1209
G. Deng, A sensitive non-radioactive PCR-RFLP analysis for detecting point mutations at 12th codon of oncogene c-Ha-ras in DNAs of gastric cancer. Nucleic Acids Research. ,vol. 16, pp. 6231- 6231 ,(1988) , 10.1093/NAR/16.13.6231
D A Spandidos, I B Kerr, Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum British Journal of Cancer. ,vol. 49, pp. 681- 688 ,(1984) , 10.1038/BJC.1984.108