Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model
作者： Tomomi Matsukura , Chisako Inaba , Esther A. Weygant , Daiki Kitamura , Ralf Janknecht
DOI: 10.14814/PHY2.14172
关键词:
摘要: Treatment modalities for kidney disease caused by long-term exposure to heavy metals, such as cadmium (Cd), are limited. Often, chronic, environmental metal is not recognized in the early stages; therefore, chelation therapy an effective option. Extracellular vesicles (EVs) derived from stem cells have been demonstrated reduce pathology both acute and chronic models. To test ability of EVs human bone marrow mesenchymal (hBM-MSCs) treat Cd damage, we generated a Cd-exposed medaka model. This model develops metal-induced cell damage various organs tissues, shows decreased overall survival. Intravenous injection highly purified hBM-MSCs repaired apical basolateral membranes mitochondria proximal tubules, glomerular podocytes, deformation, improved Our system also serves with which study age- sex-dependent injuries agents diseases. The beneficial effects on tissue repair process, shown our novel model, may open new broad avenues interventional strategies.
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