Regeneration Processes in the Kidney after Acute Injury: Role of Infiltrating Cells

摘要: The transient presence of infiltrated leukocytes in the kidney during acute renal failure as well location these cells within interstitium suggest their association with tubular injury and/or regeneration. To date, however, neither a positive nor negative contribution to pathophysiology this disease could be unambiguously demonstrated. Ill-defined methods for identifying interstitial have added controversy concerning role inflammatory current literature survey presents qualitative description accumulation observed some models, special attention those displaying necrosis particular nephron subsegments. We conclude that lethal or sublethal epithelial following toxic ischemic insults leads manifestation an mononuclear cell infiltrate. Whereas macrophages and T lymphocytes almost invariably take part, former being dominant population respect both magnitude over time, polymorphonuclear seem significantly increased only case pyelonephritis. Infiltrating often been regarded rather harmful tissue, mainly due quite understood injuring capacity latter. On other hand, we speculate through potential producing different cytokines growth factors (FGF, TGF-α, EGF-like, IL-2, etc.) might play initiating mediating regeneration after necrosis. Therefore, infiltrating injury/regeneration process remains highly controversial should further elucidated.