Evidence for the release of 1-methyl-4-phenylpyridinium (MPP+) from rat striatal neurons in vitro.
作者： Hans H. Keller , Mosé Da Prada
DOI: 10.1016/0014-2999(85)90304-8
关键词:
摘要: Abstract [ 3 H]MPP + (1-[methyl- H]4-phenylpyridinium) is taken up into rat striatal slices in a temperature-, time- and Na -dependent process blocked by dopamine (DA) uptake inhibitors. Once up, authentic released at 37°C 15 mM KCl. This release inhibited (−)N-propyl-norapomorphine enhanced (−)sulpiride, as observed under the same conditions for H]DA release. Thus, DA-ergic nerve endings do not discriminate between DA MPP their active transport autoreceptor-regulated
elsevier.com
sci-hub.se 参考文章(9)
Burkard Wp, Schaffner R, Scherschlicht R, Haefely We, Pieri M, Da Prada M, Carruba Mo, Bonetti Ep, Keller Hh, Diclofensine (Ro 8-4650)--a potent inhibitor of monoamine uptake: biochemical and behavioural effects in comparison with nomifensine. Advances in biochemical psychopharmacology. ,vol. 31, pp. 249- ,(1982)
Jan N. Johannessen, Chuang C. Chiueh, Richard S. Burns, Sanford P. Markey, IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects Life Sciences. ,vol. 36, pp. 219- 224 ,(1985) , 10.1016/0024-3205(85)90062-1
M. Da Prada, A.M. Cesura, R. Kettler, G. Zürcher, W.E. Haefely, Conversion of the neurotoxic precursor 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine into its pyridinium metabolite by human platelet monoamine oxidase type B Neuroscience Letters. ,vol. 57, pp. 257- 262 ,(1985) , 10.1016/0304-3940(85)90501-4
R. Stanley Burns, Peter A. LeWitt, Michael H. Ebert, Henning Pakkenberg, Irwin J. Kopin, The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The New England Journal of Medicine. ,vol. 312, pp. 1418- 1421 ,(1985) , 10.1056/NEJM198505303122203
J. A. Javitch, R. J. D'Amato, S. M. Strittmatter, S. H. Snyder, Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 2173- 2177 ,(1985) , 10.1073/PNAS.82.7.2173
S. P. Markey, J. N. Johannessen, C. C. Chiueh, R. S. Burns, M. A. Herkenham, Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature. ,vol. 311, pp. 464- 467 ,(1984) , 10.1038/311464A0
Catherine Mytilineou, Gerald Cohen, Richard E. Heikkila, 1-methyl-4-phenylpyridine (MPP+) is toxic to mesencephalic dopamine neurons in culture Neuroscience Letters. ,vol. 57, pp. 19- 24 ,(1985) , 10.1016/0304-3940(85)90034-5
P. VAN DER ZEE, H. S. KOGER, J. GOOTJES, W. HESPE, ARYL 1,4-DIALK(EN)YLPIPERAZINES AS SELECTIVE AND VERY POTENT INHIBITORS OF DOPAMINE UPTAKE ChemInform. ,vol. 12, ,(1981) , 10.1002/CHIN.198102262
Burkard Wp, Schaffner R, Haefely W, Launay Jm, Da Prada M, Bonetti Ep, Keller Hh, Some neuropharmacological effects of Ro 11-2465--a novel tricyclic antidepressant with potent inhibitory activity on the uptake of 5-HT. Advances in biochemical psychopharmacology. ,vol. 31, pp. 235- ,(1982)