Acute electrophysiological and neurochemical effects of administration of MPTP in mice

摘要: Abstract The changes occurring during the first few hours after subcutaneous administration of catecholaminergic neurotoxin l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were investigated. Injections MPTP (30–60 mg/kg s.c.) reduced impulse rate by 12–45% in all dopaminergic neurones tested pars compacta substantia nigra. Depressions maximal at 11 min and remained present for more than 2 hr injection. This effect was completely abolished prior catecholamine uptake inhibitor, nomifensine (13–69 s.c.), which prevents toxic metabolite 1-methyl-4-phenylpyridine (MPP+) from entering neurones. These results suggest an intraneuronal mechanism underlying observed depressions rate. Levels dopamine (DA) decreased 3 (50 60% 54% striatum nigra, respectively. Pretreatment with (25 mg/kg, intraperitoneally) prevented decrease DA only striatum. suggests acute DA-releasing striatum, mediated intracellular accumulation MPP+, while not explaining depression activity a different time course.