Management strategies in pancreatic cancer.

摘要: Purpose Current first-line and adjuvant chemotherapeutic strategies for management of patients with pancreatic cancer are reviewed. Summary Pancreatic adenocarcinoma is the 10th most prevalent fourth common cause deaths in United States. More than 80% diagnosed locally advanced or metastatic disease not candidates surgery; these often require multimodal treatment. The widely used chemotherapy such patients, as well requiring therapy after surgery, gemcitabine gemcitabine-based chemotherapy. All current chemotherapies associated dose-limiting hematologic toxicity other adverse effects that ongoing monitoring dosage adjustment to balance benefits risks Pharmacists can play an important role providing drug information guidance oncologists. investigational include efforts improve response rates outcomes through modulation cell signaling pathways use nanotechnology delivery. Conclusion multifaceted, involving anticancer therapy, supportive care, management. Standard systemic a single agent combination cytotoxic agents provides modest terms symptom control.