Origin and biology of cancer metastasis

摘要: Metastasis, the spread of cells from a primary neoplasm to distant sites where they grow, contributes death most cancer patients. The process metastasis is not random. Rather, consists series linked, sequential steps that must be completed by tumor if develop. Thus, metastatic succeed in invasion and embolization, survive circulation, arrest capillary bed, extravasate into multiply organ parenchyma. Although some this contain stochastic elements, as whole favors survival growth few subpopulations preexist within parent neoplasm. Moreover, metastases can have clonal origin, different originate proliferation single cells. outcome depends on interaction with environments. Organ-specific been demonstrated variety experimental systems, even one organ, site-specific found. conclusion highly selective influenced both intrinsic properties host factors optimistic. A regulated therefore studied then manipulated.