Angiotensin II and coronary artery disease, congestive heart failure, and sudden cardiac death.

摘要: An activated renin-angiotensin system is a major risk factor for cardiovascular events. Angiotensin II acts on AT1 and AT2 receptors. Stimulation of receptors associated with ¶• endothelial dysfunction, mainly as the consequence an increased vascular production superoxide radicals, vasoconstriction, platelet activation, enhanced release plasminogen activator inhibitor-1, activation immediate early genes c-fos c-jun, myocyte hypertrophy, connective tissue formation, endothelin-1 synthesis, growth factors like PDGF TGF-β1. ¶Stimulation can mitigate or abolish promoting effects receptor stimulation. The contribution these – single in combination progression atherosclerotic lesions, phenomenon restenosis process remodeling heart failure being progressively elucidated. With increasing knowledge about relationships inhibition appears main target preventive reparative strategies diseases.