Evidence-based indications for thrombophilia screening.

摘要: Thrombophilic defects have been shown to be associated with an increased risk of venous thrombosis, fetal loss, and gestational complications. The knowledge about the clinical relevance thrombophilic is increasing, evidence-based indications for thrombophilia screening are therefore discussed in this review. Selective based on previous personal and/or family history thromboembolism more cost-effective than universal all patient groups evaluated. In majority patients acute results do not influence duration oral anticoagulation. only population who clearly profits from situation a newly diagnosed antiphospholipid syndrome, because prolonged anticoagulation can avoid high incidence recurrence population. Because thrombosis during pregnancy puerperium, indicated selected or positive history. Significant associations early late loss observed carriers heterozygous factor V Leiden mutation, prothrombin-mutation G20210A anticardiolipin antibodies, while protein S deficiency significantly loss. Antithrombotic drugs like UFH, LMWH low-dose aspirin may potential therapeutic benefit recurrent thrombophilia, but placebo-controlled, multicenter trials urgently needed clarify issue. Although supra-additive effect between contraceptives some thrombophilias, absolute low premenopausal women mass strategies unlikely effective. While antibodies known arterial heritable thrombophilias useful although subgroup analysis indicates that they play role particularly young children.