Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome

摘要: Background  Chronic venous leg ulcers (CVU) cause considerable burden of disease for the patients as well enormous costs health care systems. The pathophysiology CVU is complex and not entirely understood. So far reliable pathogenic and/or prognostic parameters have been identified. Objectives  We studied role thrombophilia in referred to a University dermatology department treatment CVU. Patients methods  A cohort 310 with active chronic (CEAP 6) was stratified into two comparably large groups according presence or absence post-thrombotic syndrome (PTS+; PTS−) determined using duplex scan phlebography. In addition, several were assessed. Results  prevalence protein S deficiency factor V Leiden mutation significantly higher PTS+ compared PTS− group. However, both subgroups revealed high prevalences (antithrombin deficiency, C activated resistance, elevated homocysteine). Conclusion  Based on these data, it conceivable that contributes pathogenesis CVU, possibly through induction microcirculatory dysregulations.