Disclosure of APOE Genotype for Risk of Alzheimer's Disease
作者： Robert C. Green , J. Scott Roberts , L. Adrienne Cupples , Norman R. Relkin , Peter J. Whitehouse
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摘要: Background The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but genotyping patients and their family members has been discouraged. We examined effect disclosure in a prospective, randomized, controlled trial. Methods randomly assigned 162 asymptomatic adults who had parent with disease to receive results own APOE (disclosure group) or not such (nondisclosure group). measured symptoms anxiety, depression, test-related distress 6 weeks, months, 1 year after nondisclosure. Results There were no significant differences between two groups changes time-averaged measures anxiety (4.5 group 4.4 nondisclosure group, P=0.84), depression (8.8 8.7, respectively; P=0.98), (6.9 7.5, P=0.61). Secondary comparisons subgroup sub...
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Anticipating response to predictive genetic testing for Alzheimer's disease: a survey of first-degree relatives. Gerontologist. ,vol. 40, pp. 43- 52 ,(2000) , 10.1093/GERONT/40.1.43
L Adrienne Cupples, Lindsay A Farrer, A Dessa Sadovnick, Norman Relkin, Peter Whitehouse, Robert C Green, Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study. Genetics in Medicine. ,vol. 6, pp. 192- 196 ,(2004) , 10.1097/01.GIM.0000132679.92238.58
J Scott Roberts, Melissa Barber, Tamsen M Brown, L Adrienne Cupples, Lindsay A Farrer, Susan A Larusse, Stephen G Post, Kimberly A Quaid, Lisa D Ravdin, Norman R Relkin, A Dessa Sadovnick, Peter J Whitehouse, John L Woodard, Robert C Green, Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial. Genetics in Medicine. ,vol. 6, pp. 197- 203 ,(2004) , 10.1097/01.GIM.0000132688.55591.77
Susanne B Haga, Muin J Khoury, Wylie Burke, Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nature Genetics. ,vol. 34, pp. 347- 350 ,(2003) , 10.1038/NG0803-347
Norman Relkin, Kimberly Quaid, Robert H. Pietrzak, Adrienne L. Cupples, Lindsay A. Farrer, Tamsen Brown, Robert C. Green, Scott J. Roberts, Susan A. LaRusse, Heather Katzen, Peter J. Whitehouse, Melissa Barber, Stephen G. Post, Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease. Alzheimer Disease & Associated Disorders. ,vol. 17, pp. 86- 93 ,(2003) , 10.1097/00002093-200304000-00006
Adam J. Wolfberg, Genes on the Web — Direct-to-Consumer Marketing of Genetic Testing The New England Journal of Medicine. ,vol. 355, pp. 543- 545 ,(2006) , 10.1056/NEJMP068079
Lindsay A. Farrer, Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease JAMA. ,vol. 278, pp. 1349- 1356 ,(1997) , 10.1001/JAMA.1997.03550160069041
Peter J. Neumann, James K. Hammitt, Curt Mueller, Howard M. Fillit, Jerrold Hill, Nii A. Tetteh, Kenneth S. Kosik, Public Attitudes About Genetic Testing For Alzheimer’s Disease Health Affairs. ,vol. 20, pp. 252- 264 ,(2001) , 10.1377/HLTHAFF.20.5.252
Dennis Choi, Alzheimer's disease research Neurobiology of Aging. ,vol. 15, pp. 49- ,(1994) , 10.1016/0197-4580(94)90167-8
Nathan J. Zilberg, Daniel S. Weiss, Mardi J. Horowitz, Impact of Event Scale: a cross-validation study and some empirical evidence supporting a conceptual model of stress response syndromes. Journal of Consulting and Clinical Psychology. ,vol. 50, pp. 407- 414 ,(1982) , 10.1037/0022-006X.50.3.407