Surgical management of liver metastases from uveal melanoma: 16 years' experience at the Institut Curie.

摘要: Abstract Background Uveal melanoma is characterised by a high prevalence of liver metastases and poor prognosis. Aim To review the evolving surgical management this challenging condition at single institution over 16-year period. Patients Methods Between January 1991 June 2007, among 3873 patients with uveal melanoma, 798 had metastases. We undertook detailed retrospective their clinical records procedures. The data was evaluated both uni- multivariate statistical analysis for predictive survival indicators. Results 255 underwent resection. median interval between ocular tumour diagnosis surgery 68 months (range 19–81). Liver either microscopically complete (R0; n  = 76), incomplete (R1;  = 22) or macroscopically (R2;  = 157). overall postoperative 14 months, but increased to 27 when R0 resection possible. With analysis, four variables were found independently correlate prolonged survival: an from primary >24 comprehensiveness (R0), number resected (≤4) absence miliary disease. Conclusions Surgical resection, possible, able almost double appears present optimal way improving prognosis in metastatic melanoma. Advances medical treatments will be required further improve survival.