Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults
作者： Ying Huang , James O Ogutu , Jiarui Gu , Fengshu Ding , Yuhong You
DOI: 10.1155/2015/168292
关键词:
摘要: The objective of this study was to compare quinolone resistance and gyrA mutations in clinical isolates Klebsiella pneumoniae Escherichia coli from Chinese adults who used the preceding month children without any known history administration. antimicrobial susceptibilities 61 79 were determined. resistance-determining regions gene detected by PCR DNA sequencing. Fluoroquinolone types compared statistically analyzed. No significant differences rates ciprofloxacin levofloxacin between among two species (all P > 0.05). double mutation Ser83→Leu + Asp87→Asn ciprofloxacin-resistant occurred 73.7% 67.9% adults, respectively (P = 0.5444). Children with no administration found carry fluoroquinolone-resistant Enterobacteriaceae isolates. occurrence major similar those adults. results indicate that precautions should be taken on environmental issues resulting widespread transmission resistance.
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