High platelet count is associated with low bone mineral density: The MrOS Sweden cohort.

摘要: In elderly ambulatory men, high platelet and neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with BMD, but this relationship seems be dependent on estradiol osteocalcin. Blood cells exist in close proximity each other the marrow. Accumulating evidence, from both preclinical clinical studies, indicates that these cell types interconnected. Our hypothesis was BMD measurements blood count variables remodeling markers. We analyzed variables, markers, subjects MrOS cohort Gothenburg, Sweden. Men at least one variable (hgb, white count, or count) were included current analysis (n = 1005), median age 75.3 years (range 69–81 years). results show all sites (total hip BMD; r = − 0.11, P = 0.003). No statistically significant association seen between Neutrophil negatively total body (r = − 0.09, P = 0.006) (r = − 0.08, P = 0.010), positively serum ALP (r = 0.15, P < 0.001). Hgb (r = 0.16, P < 0.001), osteocalcin (r = − 0.13, The adjustments covariates, hgb observations support of an interplay components.