Chronic myeloproliferative neoplasms and risk of osteoporotic fractures; a nationwide population-based cohort study

摘要: Summary Patients with systemic mastocytosis have an increased risk of osteoporosis, however, the osteoporotic fractures among classic chronic myeloproliferative neoplasms (CMPN), including essential thrombocythaemia (ET), polycythaemia vera (PV) and myeloid leukaemia (CML), is unknown. We conducted a population-based cohort study to determine three cohorts patients newly diagnosed ET, PV, CML. Patients were identified in medical registers all Danish hospitals during 1980–2010 followed until first fracture. Fracture was compared from general population matched on age, sex calendar year. 7595 CMPN 338 974 comparison members. found that femoral fracture after 5 years consistently higher than population, being 3·01% (95% confidence interval (CI): 2·20–4·10), 4·74% (95%CI: 4·06–5·52) 4·64% 3·29–6·53) CML respectively. Adjusted hazard ratio for 1·19-fold CI: 0·94–1·51) ET patients, 1·82-fold 1·62–2·04) PV 2·67-fold 1·97–3·62) patients. conclude are at population.