Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line

摘要: Human pancreatic cancer cell lines such as PANC-1 have an altered metabolism, enabiling them to tolerate and survive under extreme conditions of nutrient starvation. The search for candidates that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. A methanol extract the bark Mangifera indica was found survival human cells preferentially nutrient-deprived with PC50 value 15.5 μg/mL, without apparent toxicity, normal nutrient-rich conditions. Chemical investigation on this bioactive led isolation 19 compounds (1–19), including two new cycloartane-type triterpenes, mangiferolate (1) B (2). structures 1 2 were determined by NMR spectroscopic analysis. Among isolated compounds, (2) isoambolic acid (12) exhibited potent preferential cytotoxicity against under...