Expression of the Polycomb-Group protein BMI1 and correlation with p16 in astrocytomas an immunohistochemical study on 80 cases.

摘要: A number of studies on the putative relation between Polycomb-Group (PcG) proteins overexpression and carcinogenesis have been published recently. BMI1, prototype PcG gene, is critically involved in cell cycle control differentiation, despite regulatory role demonstrated central nervous system (CNS) development, its implication brain tumorigenesis scarcely known. Moreover, to best our knowledge, large human tumors tissue are lacking. To gain a new insight, we tested 80 primary astrocytomas for BMI1 expression using immunohistochemistry established correlation with p16, negatively regulated target function. Fifty-four cases (72.5%) were + /p16-, 22 (27.5%) /p16+. Slight non-significant differences noted profile grades II, III, IV astrocytomas. However, when /p16+ examined cytologically, substantial proportion contained significant gemistocytic component, which thought be an adverse prognostic factor or display high degree anaplasia, suggesting common molecular mechanism BMI1/p16 pathway disruption, may implications.