Role of gemistocytes in astrocytoma progression.

摘要: The presence of gemistocytes in low-grade astrocytomas is regarded as a sign poor prognosis because the majority gemistocytic rapidly progress to anaplastic astrocytoma or glioblastoma. To elucidate role progression, we assessed fraction neoplastic gemistocytes, bcl-2 expression, p53 mutations, immunoreactivity (PAb 1801), and proliferative activity (MIB-1) 40 (World Health Organization (WHO) Grade II) with histologically proven progression (WHO III) glioblastoma IV). Astrocytoma took significantly less time patients containing more than 5% (35 months) those lesions (64 months; p = 0.038). All 11 contained mutation, whereas incidence mutations was 61% (p 0.017). In astrocytomas, labeling index (Ll) (7.4%) higher all tumor cells (3.2%, 0.0014). Gemistocytes showed expression cells, mean LI 15.6% versus 2.7% 0.0004), 20.9% 3.0% 0.002), 30.2% 5.2% glioblastomas 0.0002). contrast, lower proliferating MIB-1 0.5% 2.6% 1.5% 11.6% astrocytoma, 1.7% 16.6% < 0.0001). These data show that significant typically carry mutation. vast are, however, nonproliferative state (G o Phase cell cycle), which suggests terminal differentiation. Their accumulation within may be due bcl-2-mediated escape from apoptosis.