Coagulopathy in the prostate cancer patient: prevalence and clinical relevance.

摘要: Carcinoma of the prostate has historically been associated with bleeding diathesis which accompanies disseminated intravascular coagulation. We have performed a prospective study into prevalence coagulopathy in patients untreated cancer using matched benign prostatic hypertrophy (BPH) as controls. Haemostatic activation was assessed by measuring fibrinopeptide A (FpA) an ELISA and D-dimer latex agglutination assay. FpA levels were correlated serum specific antigen (PSA) bone scan status. Of patients, 40% had elevated FpA, being higher those positive disease (P < 0.05). detectable 24% but none BPH. Neither nor related to PSA appeared be predictor status predictive value 91%. It is concluded that changes compatible subclinical DIC are common presenting measurement may roles tumour markers this disease.